Chidambaram Ramanathan, PhD
Dr. Ramanathan obtained a PhD in behavioral neurobiology at Madurai Kamaraj University, Madurai, India. His doctoral research focused on behavioral and neurobiological aspects of biological clocks in mammals. Dr. Ramanathan’s research efforts have been directed towards addressing gaps in our understanding of neural circuits and molecular mechanisms of circadian clocks which underlie circadian behavior and physiology of diurnal grass rats.At the University of Memphis, Dr. Ramanathan used functional genomic resources, gene therapy methods, and high-throughput tools to address molecular mechanisms circadian clock in cell-autonomous clock models.
Dr. Ramanathan first engineered cell-autonomous clock models in which a clock lentiviral luciferase reporter is introduced into physiologically relevant cell lines (e.g. liver-hepatocytes; fat-adipocytes) to allow for real-time in vitro monitoring of bioluminescence circadian dynamics. Dr. Ramanathan also used gene knockdown strategy to identify multiple clock modifiers and CRISPR/Cas9 reconfirm the knockdown clock phenotypes.
As a researcher with 15+ years of experience in biological sciences, cell and molecular biology, functional genomics, gene and cellular therapy, cellular & mice genetics, behavioral neuroscience, and high-throughput screening assays, Dr. Ramanathan continues to work toward the growth of CirQuest Labs as a facility that supports the pharmaceutical industry in various stages of drug development.